Prenatal Cocaine Reduces AMPA Receptor Synaptic Expression ...
Abstract
Prenatal cocaine exposure produces sustained neurobehavioral and brain synaptic changes closely resembling those of animals with defective AMPA receptors (AMPARs). We hypothesized that prenatal cocaine exposure attenuates AMPAR signaling by interfering with AMPAR synaptic targeting. AMPAR function is governed by receptor cycling on and off the synaptic membrane through its interaction with glutamate receptor-interacting protein (GRIP), a PDZ domain protein that is regulated by reversible phosphorylation. Our results show that prenatal cocaine exposure markedly reduces AMPAR synaptic targeting and attenuates AMPAR-mediated synaptic long-term depression in the frontal cortex of 21-d-old rats. This cocaine effect is the result of reduced GRIP–AMPAR interaction caused by persistent phosphorylation of GRIP by protein kinase C (PKC) and Src tyrosine kinase. These data support the restoration of AMPAR activation via suppressing excessive PKC-mediated GRIP phosphorylation as a novel therapeutic approach to treat the neurobehavioral consequences of prenatal cocaine.
Osteopathic School Of Medicine Stratford Nj - Bookshelf
Of mice and men
The tragic story of the friendship between two migrant workers, George and mentally retarded Lenny, and their dream of owning a farmThree Cups of Tea
Elements of Style
The Elements of Style is a classic work which is intended for use in English courses in which the practice of composition is combined with the study of ...The Grapes of Wrath
Depicts the hardships and suffering endured by the Joads as they journey from Oklahoma to California during the Depression.A Confederacy of Dunces
The novel astonishes with its inventiveness; it lives in the play of its voices. A Confederacy of Dunces is nothing less than a grand comic fugue.Electronic Information Directory
School of Osteopathic Medicine at UMDNJ
UMDNJ-SOM (University of Medicine and Dentistry, New Jersey School of Osteopathic Medicine) offers Osteopathic medical education, graduate medical education, medical ...
UMDNJ – School of Osteopathic Medicine - Wikipedia, the free ...
The School of Osteopathic Medicine (abbreviated SOM, also known as UMDNJ-SOM) is one of eight schools that form the University of Medicine and Dentistry of New Jersey. ...
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